The Reading Room features publications and links to information relevant to the science and technology under development at Casterbridge Pharmaceuticals Inc.

Grant Awards:

 

Hepatitis B Virus publications:

“Chemical Approaches to inhibiting the Hepatitis B Virus Ribonuclease H”: https://www.ncbi.nlm.nih.gov/pubmed/29565562

“Efficacy of hepatitis B virus ribonuclease H inhibitors, a new class of replication antagonists, in FRG human liver chimeric mice.”: https://www.ncbi.nlm.nih.gov/pubmed/29129708

“A research agenda for curing chronic hepatitis B virus infection.”: https://www.ncbi.nlm.nih.gov/pubmed/28877549

Herpes Simplex Virus publications:

“Broad anti-herpesviral activity of α-hydroxytropolones”: https://www.ncbi.nlm.nih.gov/pubmed/29408023

“Synthetic α-Hydroxytropolones Inhibit Replication of Wild-Type and Acyclovir-Resistant Herpes Simplex Viruses.”: https://www.ncbi.nlm.nih.gov/pubmed/26787704

Novel chemical synthesis for drug R&D:

Hirsch, D. R.; Schiavone, D. V.; Berkowitz, A. J.; Morrison, L. A.; Masaoka, T.; Wilson, J. A.; Lomonosova, E.; Zhao, H.; Patel, B. S.; Dalta, S. H.; Majidi, S. J.; Pal, R.; K.; Gallicchio, E.; Tang, L.; Tavis, J. E.; Le Grice, S. F. J.; Beutler, J. A.; Murelli, R. P. “Synthesis and Biological Assessment of 3,7-Dihydroxytropolones” Org. Biomol. Chem. 2018, 16, 62-69. (link)

D’Erasmo, M. P.; Murelli, R. P. “Fluorous-Phase Approach to α-Hydroxtropolone Synthesis” J. Org. Chem. 2018, 83, 1478-1485. (link)

Berkowitz, A. J.; Abdelmessih, R. G.; Murelli, R. P. “Amidation Strategy for Final-Step α-Hydroxytropolone Diversification” Tetrahedron Lett. 2018, 59, 3026-8. (link)

Meck, C.; D’ Erasmo, M. P.; Hirsch, D. R.; Murelli, R. P. “The biology and synthesis of α-hydroxytropolones” Med. Chem. Commun. 2014, 5, 842-852. (link)